After reading all the previous posts, the only thing I see that has been left out is the throat erosion that can occur, espically when loading hot 22-250 rounds.
In my experience there seems to be less erosion with the .223 than either the 22-250 or the 220 Swift. Hot loaded rounds that create erosion reduce barrel life and accuracy.
Yes, 4000+ f.p.s. can be a lot of fun, but it comes with a price...
All that said, my vote goes to the .223 or even the new .204 Ruger!