If you look back at one of my posts I asked the same question. After mutiple powders and bullets I have found the one that is great in my gun. I'm using 66gr. of reloader 22 with 150 gr nosler partitions. I was all over the place when I first started (8-10" groups) but now have a great load that shoots 1" groups at 100 yds. It's worth trying different brands of powders...most people suggested IMR but as soon as I used R22 almost everything I shot out of my gun was grouping well. From that, I tried different bullets and now will play with seting depth. Good luck! JDinAB