If you pick an exit hole that would make you hit or miss high, then you need to pick a different exit hole.[:-]
It's like throwing a jab. You want to hit the nose but you swing for a point about 3" behind the point of the nose to really give your opponent a good nosebleed.
First thing to do is study your quarry's internal anatomy. Learn the location of all major bones and vital organs and how they lie within the animal. Then you are able to visualize where the organs are inside the chest cavity, then visualize the track the arrow will have to take to get both lungs, both lungs and the heart.... When you get good at visualizing the internal structure of an animal's anatomy, it's almost like you've got Superman's x-ray vision. No matter what angle the animal is to you, you can practically see where the organs and major bones are. That tells you about where the exit hole needs to be on the other side. Pick the location you need for the entrance hole where it will track through the vitals, but aim for the exit hole.