Well, that would depend on the use. I would throw out the WBY right away because of the cost and availability of the brass and ammo. For extremely long shots, beyond 400 yds or so, I would take the Ultra, but I wouldn't even want to take a shot at an animal at that range anyway. For all practical purposes, I see no more need for anything more powerful (in the .30 class) than the .300 Win. It can handle anything on the continent with out looking back, the ammo is cheaper, barrel life longer, and it has stood the test of time. If I wanted more power for bigger game, then I would go completely into the next few classes of calibers and snag a .375 H&H!