"In general" a "cast" bullet out of a 44 mag. will have more velocity than a "jacketed" bullet of the same weight with the "same load". Heavier bullets will out penetrate lighter ones. AND, if you cast the bullets "too hard", they will break up when they hit bone!
So, you have to decide what the bullet will be used for, and then pick the bullet for "that" job.
Drilling Man