I'm a die hard Ruger fan and swear by Ruger firearms.Though I have never owned one of their semi autos (except the MKII's 22's)I have no first hand experience with them.I know several people who have the Rugers and are very happy with them.For self protection at a reasonable price I'd say go with the Glock's.I carry a Baby Glock M-27 in 40 cal. I couldn't ask for a better carry gun.I had Trijicon Night Sights installed.They are the ticket for night time carrying.Like others have mentioned look at several guns. Handle them ,see if they fit you well.All we can do is give you our opinions.It's up to you to see which one fills your needs. I would stay away from the cheaper semi auto's. If you're going to put your life on the line make sure you have a reliable gun in case you need to use it.
Ruger Redhawk