Bronko wrote: "150s are great but somewhere past 200-250 yards, the 180s shoot flatter"

How do the 165s compare, in the equation? My 300RUM likes 165s and of course, I am able to get higher MV, then with the 180s, which produces flatter trajectory. Am I losing a lot, in terms of killing power past 250yds., when compared to a 180?