In general,
Barring prior injury, and provided one has the fundamentals of rifle construction/set up/fit and the techniques for handling higher recoil firearms covered (most folks just shoot "out of the box" and do not address any of them), then the issue of felt recoil and one's ability to handle felt recoil varies almost entirely by the individual's mental state and attitude.
With that said, the "bigger boys" are not intended for use as gallery guns nor target rifles to run a 100 rounds thru in one setting. Once you have established that the rifle is sighted in and you have demonstrated that you can "hit" with it from a few different field positions, then there is really no need to go any further -- volume shooting will not improve accuracy in this case. End on a good note and put it away and then switch over and reward yourself and play with something more "fun and easy" like a 30-06 etc. on down to 22LR. Always strive to "wrap up" feeling good about things, even if things go really well and you'll be finishing sooner than you expected.
At MagFest 2003, a group of us weighing from 165 to 230 shot: 7mmRemMag, 300WinMag, 338WinMag, 375H&HMag, 416RemMag, 416 Rigby, 458WinMag, and 500 NitroExpress --- everyone's general opinion was recoil? Really not a big deal! Then again the issues mentioned above for managing recoil were implemented, monitored, and enforced VERY closely --- it was a hoot.
Quoting HuntingGirl, "I kind of like a rifle that kicks a bit!" [Aggrrrr!]
EKM