RE: Lookin' for a good long range coyote rifle!
hunter, I think 4400 fps with a 50 grain bullet fired from a factory Remington 22-250 is a little optimistic. If you can get 4000 fps with no high pressure signs then you are fortunate.
Either a 25-06 or 257 WBY would be tough to beat at ranges over 400-500 yards.
doubleA