Depends on the size and durability of the game you plan on putting that 150 grainer into --- for deer almost anything will work as you can knock them over with a stick. For larger more durable animals like elk or moose a bit more serious bullet (both weight and construction) would be a favorable asset.

You can kill anything anywhere under "just so" circumstances with a 22 LR. But with that "old refrain" now quoted and out of the way, for elk I would recommend Nosler Partitions at 180 grains as a minimum and go up in size and quality from there. Like the 22LR, CoreLokt's and other soft point/thin jacket/non-partitioned bullets can do it, but I would hardly call it "top notch" equipment, especially if you are new at the "bigger than deer" game. Remote/away from home big game hunting is expensive. Even "expensive" bullets/ammo is cheap in the big picture.

My $.02, your call.

Good Luck and Good Hunting,
EKM