I shoot similar setups or have in the past and have always had complete pass throughs except on one deer with a vortex head, never not cleanly blown through when using muzzys though. As long as I get an exit hole I don't care if it sticks in the ground.

as far as the bone or not issue, i have shot through ribs and not had probs and when i first started bowhunting, shot completely through the shoulder blade of a deer using old darton 50 MX at 55 pounds 2117 arrow and a muzzy 125 head.