I've had good results on deer with Bulk Winchester 150 PSP bullets. I loaded them to around 2850-2900 fps. Usually complete penetration on broadside shots. By the size of the exit wounds I'd say they expanded well.

It really does depend on the bullet you pick, and the velocity you load it to, and even the anticipated range of the shots you anticipate taking. Generally speaking though the 150s will do fine on deer sized game.