Its Nitch truely is anything that moves. It will take small game with squib loads and has taken the African Big six several times now. It is a stopper for the biggest Bears and the smallest deer.. With 300 and 350 grain bullets it will be easy to hit with out to 150 yards and with practice will do much better. The old buffalo hunters used it to take Bison out to 300 yards with Black Powder loads. There are many bullets available for it and and its a versitile powerful weapon. As someone else said, go to the Garret cartridge site. You will be amazed at what this 110 year old cartridge can do. There is not much it can't do. I have it in Marlin , Encore and H&R as well as a Sharps replica.