The last load I worked up for my .300 Weatherby is now my favorite. Here it is:

168 gr. Barnes TSX
84 grs. RL22
Norma brass
Fed 215M primer

This combination has been very accurate for me and with the Barnes bullet you don't have to worry about how it's going to perform on game. I shoot deer up close and personal quite often, that's why I really like this bullet. It won't over-expand or disintigrate like some other bullets at high velocity.

I've also had excellent results with IMR 7828 and just about any 180 gr. bullet I've ever used, at least from an accuracy standpoint that is. I've had less than desirable results on game, however, with certain bullets I've used. The Nosler Partition is always a good choice of course. I max out at about 85 grs. of 7828 in my Sako rifle with Norma brass and Fed 215M primers when using 180 gr. bullets.

As always, your rifle is different. Start lower and work up with your powder charge.