180 grain partitions loaded with MRP (if you can find it) matches factory loadings and would be my first suggestion. 7828 is also a good powder. Some folks seem to have luck with RL22--my rifles have not shot it well. I've used the factory hornaday 165s on both elk and mule deer. I wouldn't count on it for a raking shot on elk or to take out shoulders. However, they create great wound channels. For heart lung shots on elk, they are simply devastating. Barnes TSX 168 were the first barnes bullets I've ever been able to shoot well in my rifle. They would be ideal for elk and deer if your rifle will shoot them. When you get your rifle shooting well, please post the results. Good luck.