Well i think a lot of what it has to do with is what, and where doyou like to hunt. If you are into the woods, of those three i would suggest the 30-06, but if you are after a field gun i would consider the .33, or the 7mm Rem. Mag. I happen to shot the 7mm Rem. MAg., but i don't want to be selling you that gun. I am teh hunter that likes to shoot as far as i can, as accurilty as i can so i chose that do to the power behind every shot. another thing that you can play around with is the different size of loads you have. we reload all of ours, and i have a 164 gr Hornady BTSP and love the way it mushrooms, and impacts. i have 68 grains of the pencil lead powder, with a CCI bench rest primer on it. they shoot in groups of a 1-2 inch circle from 25- 400 yards. the farthest i have had to go is 301yds. so like i said it is really up to where you like to hunt. if you are a woods hunter i would go for the 30.06, but if you like to play in teh fields go for the .300, or the 7mm Rem. Mag.