My best powder and load is I4350,using 62.5 grs and a 130 sst,win mag primers.
I would try R-19 66grs /130 gr bullett and R-22,66.5 /130 gr bullet,and see which one shoots the best in your rifle.
You didn't say what you were shooting it in,I am using a browning stalker and a win classic/ss.
So far the browning way outshoots the win classic.