I have harvested whitetail deer with several calibers like .243, .270 and the 30-06 and I reload for all these. Last summer I got an itch for a new bolt action rifle and did some research and found the .300 win. mag. offered the best of all worlds IMHO. You can load bullets as light as the 125 gr. Nosler Ballistic Tip up to the 220 gr. solids. It's a caliber you can taylor for the type hunting you plan to do. So I bought a Winchester Model 70 Sporter Classic. It's a little on the heavy side and that helps with the recoil. I took a nice 8 point buck last deer season using the 125 gr. Nosler Ballistic Tip at about 75 yrds. and he went down like I have never seen a deer go down before with the other calibers I have used. I know some of you out there are saying the 125 gr. is too light for the .300 win. mag. and it will come apart on impact and you are right to a certain degree. It's a matter of choice. I also use the load for coyote and they don't move after a hit. Next deer season I'm going to work up a load with the 165 gr. Nosler Ballistic Tip for whitetail. Go with the .300 win. mag. You will love the stopping power and accuracy that can be achieved with it. If you don't reload, there is plenty of factory ammo out there to choose from and the caliber will take anything in North America.
Good Hunting