Okay guys everybody has different opinions about the 357 Mag and deer.I'm not saying it won't kill a deer. I just think it's a little light.With proper shot placement it's deadly.If you keep within the limitations that's fine..the question is will you keep within your limitation?I doubt it,you'll try to stretch it.I know the 22 LR has taken allot of deer. That goes back to shot placement. frizzellr No,I don't use a 22 centerfire for deer.I know there are many who do. I'm not saying you have to have a cannon.I want to make the cleanest humane kills possible. With the smaller caliber if you miss with your perfect shot placement there is allot better chance of losing the deer then a hit with the larger caliber.Whatever you choose to use it's your business. soarkrebel, maybe I'm not as good a shot as you, I better stick with my Casull. Ruger Redhawk