280 ammo availability would be an issue if Wally World was the only place that sold ammo but it's not. All the gun shops in this area carry 280 but the selection, of course, isn't as varied as say 7mm Rem Mag or 270. This may be just a regional thing, many things are. Ammo also is easily purchased over the internet but you must pay S&H which increases the cost.

To get the most from the 280 you should reload but I've also had very good results with factory ammo, especially Winchester 140gr Ballistic SilverTips.