Hands down, the 280. It has all the speed that it needs to dispatch any antelope deer or Elk and even moose. Most 280 rifles just have 22 inch barrel. Mine is an NEF and has a 26 inch barrel which comes awful close to the 7MMWSM. this with a good amount less powder. IMO I have never had much use for the 338 Win Mag. I had a couple of them but would much prefer the 375 H&H when it comes to needing anything bigget than the 30-06 270 and 280 class rifles. With decent shooting the 30-06 will take about any game that the 338 Win Mag will take. However the 375 H&H is a solid step up. As I say this has been my finding.