When you see a deer thats been shot with a 55 gr. hollow point you will sing a different song. It will absolutley leave one giant hole in deer that will make your .50-06 magnumwhatever look small in comparison.
22-250 is a great gun and will not cripple deer. Some of those remarks are rediculous, it doesnt take belted magnums or large calibers to kill a deer. Put it where it counts and the work begins. The diameter of a bullet does not determine how it kills. Velocity however does.