For those only drawing/shooting a cam.5 system and making their observations on hybrids simply from that one system, I suggest you draw others such as a Merlin Omega hybrid system. Rock solid wall that can easily compare to the solos, plus it offers straight and level nock travel to boot, making it very easy to tune a variety of arrow spines in minutes.
Unlike the cam.5 which everyone is using as a benchmark of hybrids and really shouldn't be because the cam.5 is IMO more like a pure twin than it is a hybrid with it's eliptical cabletrack, the Merlin Omega and Darton CPS, (along with a few other"true" hybrids) offer a round cable track on the top idler/cam that allows true straight and level nock travel at all drawlengths and a smoother transfer of energy to boot.(more comfortable) I really thought Hoyt was going to update to this type of system in 2004 but they opted not to...I suspect they will change it up next year to be more in line with the "true" hybrid design because of it's additional attributes.
OK, back to original question---
Difference between hybrids and solos is that "true" hybrids effectively combine the best attributes of both solos and twins all into one system. They do not exhibit poor dynamic balance as solos do due to differing size/weight cams/idlers and thus differing rates of rotation and limbtip travel. True Hybrids have symmetrical cam and string profiles much like twins but without the timing issues associated with them because they are slaved-- therefore they exhibit "set and forget" tuning. They do not have super long strings that stretch easily, they're very smooth on the draw also much like a twin . They are simply a better mousetrap IMHO---evolution continues.
More and more manufacturers and archers themselves are figuring this out too----eventually I believe we will see the hybrid take over as the #1 system simply due to it's attributes over both twins and solos. Next year there will be even more companies adding hybrids to their lineups, and others will be refining theirs even more........as stated, evolution continues.

Good shooting, Pinwheel 12