For one "all-around" gun you'd be better off with the larger caliber. I have a .30-06 that I got as an "all-around" gun and although I have used it on coyotes, it isn't a varmit caliber, and I'm now looking at .22-250 or .223 for that. If I had to pick one, I'd go .270win it'll take just about anything you'll want to, but beware that you'll soon want a smaller caliber for varmits.