A couple of years back i was hunting plainsgame in Africa and i had a choice of 2 weapons i.e. the 375 H&H and the 300 WB Mag.Although the H&H is a real stopper i definately preferred the WB and shot all my animals with this weapon.I found it to be a good allround rifle,one which should be suitable for American game.The other caliber i'm inclined towards is the 7mm.Rem.mag.with 160 grain bullets.I've used this weapon extensively and found it to be a good long range rifle.For long range shots on small animals i prefer the 22.250,being both light and accurate.However i'm open to suggestions as who would know better than you guys.