Once at a deer a very long time ago - LOTS OF FEVER GOIN ON - The buck was running I was running. REALLY STUPID ON MY PART. Missed the entire western half of the universe.
Tried a head shot once also - ANOTHER REALLY STUPID ON MY PART THING. Now 20+years later I only shoot at the vital area and only if I am sure and only if I am standing or kneeling.
The game I've managed to take were all within 150 yards, not aware of my presence and went down without a fuss.
EDIT POINT: I took a shot once that gave me the runs