It's probably a toss up. I'm looking at a .223 for 'yotes, but then again, around here, maximum range for a shot is under 200yrds. If you're thinking your going to be shooting farther than that, look at one of the faster rounds, .22-250, .220swift, or .223wssm. Also remember that the .223 is going to be cheaper to shoot, even when you reload you still have to put more powder in the .22-250 to get those higher velocities. That said, I would also love to have a .22-250, maybe next year....