7mm Rem Mag is my choice as my all arounder. It is flat for long range shot ops, big enough to handle the likes of bull moose or elk and does wonderfully on deer. The 280 is a solid choice but up here ammo is as much as the 7 rm mag, harder to find and less choice which in that case makes it less favorable for my area. The 270 is an excellent deer cartridge and can be used for bigger animals such as elk or moose but one must limit both distance and shot angles to ensure the best results. Bullet selection is key with most cartridges but more paramount with the 270 for the bigger critters. I still own a 270 and have used it previously on bothe elk and moose with no problems bit a solid bullet/proper limitations used...I would have no problems using it for the odd bigger game hunt but if it was more than odd elk or moose or where shots would be stretched it may not be the best choice. 3006 does everything but nothing great, it is a ok choice...just wouldn't be mine. If I just needed a 30 cal I would go with the 300.

Best of luck