I know there is alot of opinion on this one because both have already taken everything that can be taken. Can one do it better than an other? Don't know about that either. But what I do know is this: You said to take anything else that gets in your way. Well, if that means somewhere down the road running into some mighty big, tuff game on another continent then I would have to suggest the .308 win. Reason being is the bullet variety. There is such a huge selection of bullets styles and weights to cover anything from varmints to truly big game in the 30caliber. However, the .270 by consensus will shoot a little further and flatter. Good Luck but my choice would be the .308win.