RE: .22-250??!!
IMO, all .22 centerfires are varmint calibers only!
As Clint asks "why?"
The only half decent reason would be that that's the gun you own. Other than that calibers like the .243/6MM are much better minimum calibers, with not much more recoil than the .22's!
Do they work? Yes but .177 pellet gun will too, but that doesn't make it a deer gun!