If you have to ask then I think you shouldn't. I have taken 2 Deer with my 22-250.
Why......... Because I can.I can hit a dime at 100 yards everytime with my 52 grain hollowpoints.
Like everyone here says it's shot placement.
I can rip the head off a Gopher at 200 and have no problem with a heart shot at 100 on a Deer.