I think the biggest thing the "pros" have all over the rest of us mere mortals is the ability to repeat their shot. I recently read Bernie Pellerite's book, Idiot Proof Archer, and he stated that even a bow way out of whack, illustrated with a hooter shooter, will stack arrows all day long. He also stated that Terry Ragsdale (I think that's who it was) set his record at Vegas with a bow shooting a 5" left tear or something really frigged up like that.
Do the same thing over and over if you're good enough, cam systems don't matter.
Now, for the rest of us, I think they do matter, just not sure to what extent. I believe that most "bowhunters" who pick up their bow a week before season, shoot a few arrows and head for the tree, will shoot better with a good single, due to the solid wall giving them a repeatable anchor. My B-I-L lost deer after deer in the heat of the moment when using a mushy wall 2 cam, most probably due to inconsistent anchor, but in front of a target he had time to hone in. This year, with an '02 high brace extreme solo, he was 3 for 3, all pass throughs, from 10-30 yards. His confidence levels are through the roof, needless to say.
I'm sure a hybrid exhibiting straight and level nock travel will be easier to tune, but if one is aware of potential shortcomings and prepares for them with say proper spine, etc, getting a good tune shouldn't be too much of an issue with any modern bow.
I was really looking forward to Pinwheel's take on things

Perhaps he can link an article or something from another tech that will enlighten us...