A Glock is a fine choice, and because of their popularity they can be had for less then what many other semi-auto's cost. I absolutely love my Glock 21 (.45ACP). It's a great shooter, recoil is surprizingly mild for a .45, but Glocks are known for being mild shooters. The only thing that non-stock is the 3.5lb. disconnector. It's also very reliable with anything but the el-cheapo Wolf ammo. My Glock didn't eject the Wolf steel cases very well and it stovepiped a couple times. With Winchester USA JRN and UMC JRN's, as well as Federal Hydra-shoks it has never malfunctioned for me.
As far as cost, it depends on what model you want. New ones are usually in the $475-550 range. Used Glocks are common and can be had for around $400 and up depending on model and condition. I paid $525 for mine used, but it is one of the "America's Heroes 9/11/01" commemorative Glocks. It's one of 1000 made in .45ACP. It's also, to my knowledge, the only special edition Glock has done with their Model 21, making it very rare. It'll probably be worth a little bit of money someday, but I don't think I'll ever sell it.
Mike