We run dogs over yotes and my experience has been that unless you have dogs to go catch em you don't want to shoot the 22 mag or .17. We've found everything from the 222 on up work just fine. Then again , were shooting running animals most times except when they stop to listen for the dogs in range so were not always dead center in thier chest, though the one I shot in the chest frontwards with the 22mag at 20 yards we didn't get. Don't really know except the shot felt really good but the results were not. Upgraded from that point to 22 250. Enjoy and good hunting. Juniorpc.