its prty much up to you on that. i jus bought a used savage 223 and shoots great. i jus like the 223 so thats what i got. 22-250 is a good gun also. i would say that if p dog hunting 223 would be more than good. but for yote hunting maybe 22-250 would get alittle longer. but i jus bought my 223 for yote. and i bought it from a taxidermist who shoots winchester jhp 45 grain holopoint. he said that worked the best for yotes. no exit hole. it put a small enterence hole and then exploded rippin all the innards up.