take-em,
You can never use too much rifle. My selection would be a 25.06 in a Savage rifle and the best scope you can afford.

A lot of people like the .243, but it's a marginal caliber for deer.

A 25.06 has the same ballistics of a .22-250, but it can shoot twice as much bullet weight. It also has the versatility of a 90gr. bullet for varmints or 120gr. bullet for deer, pronghorn or black bear.

Good luck with your choices!
Good hunting, Bowhunter57