YOU HAVE TO HIT EM CORRECTLY WITH ANY CALIBER...I HAVE SHOT DEER RIGHT IN THE SHOUDER WITH 243 CALIBER USING SIERRA 85 GRAIN HOLLOW POINTS.AND ALSO HORNADAY 100 GRAINERS.FURTHEST DISTANCE..ABOUT 125 YDS...BUT I CANNOT RECCOMMEND USUNG ANY OTHER BRAND OF BULLETS AS I HAVE NO EXPERIENCE EXEPT TWO BAD ONES WITH WINCHESTER POWER POINTS IN 100 GRAINERS........SO I FEEL BULLET SELECTION CAN BE CRITICAL ESECIALLY IN THE LOWER CALIBER 243..SHOT A DEER THIS FALL IN THE LOWER CHEST WITH A 270 REMINGTON FLAT NOSE 150 GRAIN BULLET CORE LOCKED AT A DISTANCE OF ABOUT 50 YARDS ...A STRIAGHT ON SHOT WITH THE DEER FACING ME..I KNOCKED THE DEER OFF HIS FEET ..HEAD OVER HEELS...ONLY THING..WHEN I WENT TO GET THE DEER IN THE BRUSH...NO DEER...I CALLED SIERRA BULLET COMPANY TO SEE IF MAYBE REMINGTON BULLETS WERE FAULTY...THEY WOULD NOT CRITISIZE THE REMINGTON BULLET...BUT SAID THAT IT WAS PROBABLY JUST A KIND OF A FLUKE WHERE THE BULLET GLANCED OFF THE STERNUM AND KIND OF RICHOCED OFF THE RIB BONES...I HAVE SHOT A LOT OF DEEER IN THE LAST 20 YEARS PROBABLY AROUND 45 TO 50 ...WELL LIVE AND LEARN...MY SHOTS ON DEER FACING ME FROM NOW ON WILL BE HIGHER CLOSER TO THE BASE OF THE NECK..AT LEAST THATS WHAT I WILL TRY TO DO....JUST MY HUMBLE OPINION