quilly, the 223 rem will do great for yotes. i dono bout the 22lr for yotes though. good for close range. but i jus bought a 223. it was a savage and i bought it used and i shot a squirrel 3 days ago and i hit it in the head. nothin left of the head but the rest was fine. but i was shooting holopoints. a guy i talked to said the shells he gave me will enter a coyote make a small hole and then explode so there is no exit wound and he said it realy does a number on the innards of a yote. they are winchester 45 gr holopoint varment loads. prty cheap too. i thik like 10 bucks for a box of 40. i would definatly suggest a 223. have yet to shoot a yote with it but workin on it. and if u use a reg bullet like a 45 gr or smaller it will work for rabbit also.