A lot of folks hunt with an '06. I've been using 150 gr. bullets. I used to use 180's but the 150's shoot flatter, don't kick as much and the deer drop just as quick. Just like with any rifle, if I shoot them through the lungs they'll run 30 - 50 yd. and drop. A variable scope of 2x -7x or 1.5x - 6x would be perfect in my opinion.