LBRB45, I reload for my nephew's .300 Win. Mag. and I use basically the same thing you are using....180 gr. Nosler BT and RL22, Win. brass and CCI magnum primers. He shoots them out of a Remington 700 BDL stainless snythetic w/ the muzzle brake. I've seen the accuracy of this load on paper firsthand and it is excellent for a hunting load! Also, it is devastating on whitetail deer![X(]