RE: Energy vs. Velocity vs. Caliber
While doing the research, keep in mind the distances that you will most likely be hunting at. Depending on where you are, the average shot distance can vary greatly. Where I've done most of my deer hunting, there are few opportunities for shots over 100yds.
If you're getting started, I wouldn't worry about 300+ yd shots. In those cases I star thinkning more about stand placement or trying to get in closer. Just my $.02.