I have done it before on deer under the right conditions. The first deer that I ever killed kept trying to get away even after I had shot it in the chest! I was using my muzzleloader on a rainy day and it would not go off a second time. The deer kept getting further and further away until I decided that I had to stop it. I grabbed it by the horns(it was a small spike) and I proceeded to put it out of its misery. I regret that I had to slit its throat, but I would way rather take charge than to have the animal get away wounded. I think that is the most inhumane thing you can do. You owe it to the animal to do the job quickly and effectively.