Hi jdeerhunter270,

Well, I guess to a large degree it would depend on your intended use(s). But if you are talking the majority of medium and big game in the United States.....you'd be hard pressed to do better than your handle. A .270 Winchester in a rifle that you like, handles well for you, and fits you....would be hard to top.

For additional information about many calibers...and how they "stack up"...check out this site:

http://www.chuckhawks.com/index2e.rifle_cartridges.htm

There is so much useful information located there it should provide you with all you need to make an informed decision.

Good luck with your endeavor!

Dave