I have no personal experience with the .45 Colt, from a rifle or carbine. But I have experience from the .45 Colt from a handgun. It works fine on deer within its range limitations. So I could only imagine that it would be at least as effective from a rifle.

I also have handled, shot, and hunted with many Marlin lever actions over the years.....and without exception....they have been fine hunting companions. If you like the rifle, get it and use it. With the .45 Colt not all factory loads make the best choice for deer hunting. So insure you pick a load that offers suitable performance for the task at hand!

Best of luck with your decision.