I can't really tell you how much dif. you to expect from the bullets you mention and I don't really know what dif. it makes both rounds will do the job you are asking of them the 243 buck the wind better than the 22-250 and with solid bullets will do less pelt damage if that is a concern if not either one with varment style bullets will considerable damage. don't know if that helps any but my choice would be 243 for what thats worth.[8D]