You didn't mention arrow weight/type or broadhead weight.

While 45 pounds is enough to kill a deer, your arrows may be way too heavy. You could shoot lighter and faster arrows and broadheads to overcome the slow arrow speed.

That in itself may become a problem with a reduced kinetic energy from shooting a light arrow from a 45 pound bow. It gets pretty techical.

If you are confident in what you shoot, just aim at the bottom of the body. If they duck, they duck right into a double lung shot. If not, the arrow is a clean miss.

I think you can live with either one.

Good luck!