I haven't hunted many big game animals, but I would say that a cougar or wolf would be about the toughest especially if we are talking about with a bow(this is the bowhunting forum). Those might be classified as predators, but then how's about a grizzly bear? I believe that qualifies as a big game animal. What about a black panther. I bet the few of those that run around the Florida everglades would be tough to get with a bow!

TBO