The 22-250 is the better all-around choice. If you shoot the 22-250 alot it's going to get expensive, if you do not reload?
Look at a 223 if you plan on shooting only factory ammo.
I own both a 22-250 & 223, the 223 is the gun I grab most often. I reload for both, but I just love my 223.
I will also give another vote for Savage. I have the Savage Model 12-FV chambered in 223. The thing will shoot one ragged hole hole @ 100-yards.