The biggest deer I ever killed was with a .243 80 gr boat tail hollow point. There was no exit and little blood trial for the maybe 50 yards it ran. When I field dressed it, it looked like a grenade had gone off inside of it. The bullet hit a rib, tumbled and came apart, makeing mush of heart, and lungs, I do not know how it ran at all as there was nothing that looked like a heart.