i once shot a deer when it was running full tilt across an open field. i knew what my rifle could do and lead the deer. i hit it right behind the front shoulder at an angling shot running away from me. the bullet cane out through the brisket. deer took about two or three steps and went down. by the way my rifle is a 300 H&H mag and the deer was about 50 to 75 yards away. if this would have been in the woods i would have never attempted the shot.